With PCOS, the key is restoring balance. Oestra® supports healthier cycles, mood, and metabolism by providing hormones in the right ratios for your body. Some women notice temporary bloating at first, since testosterone may be elevated — digestive support and dietary changes can help reduce this. Please see our recommendations for bloating. Stopping Oestra® is recommended monthly, every 28 days, to have a period.
Getting started
How Oestra® is different
Oestra™ is a plant-based hormone therapy designed to address the root hormonal cause of PCOS: low estrogen and progesterone, which leads to high testosterone.
Treats the root cause: Unlike birth control or metformin, which are often prescribed as a catch-all, Oestra® works to lower testosterone and restore progesterone and estradiol.
All-in-one protocol: Our treatment uses plant-based estradiol and micronized progesterone to support periods, insulin sensitivity, skin, and hair without synthetic hormones.
Smarter delivery: The vaginal application bypasses the liver, allowing for higher absorption and more stable hormone levels with minimal side effects.
Why vaginal delivery is a smart choice
Why vaginal delivery is a smart choice
Oestra® is a cream applied vaginally, which allows it to be absorbed directly into the bloodstream. This method bypasses the gut and liver, helping your hormones get where they’re needed faster and more effectively.
Systemic and highly bioavailable • Vaginal delivery bypasses liver metabolism, allowing nearly full absorption of estradiol and progesterone—far better than oral (10-20%) or topical (3-20%). This leads to more stable hormone levels and better symptom control.
More effective, fewer side effects • It delivers consistent results with fewer fluctuations and side effects. Hormone levels remain steady, improving your comfort and results. Clinical evidence—including 100+ studies—supports its effectiveness.
Proven safety • Vaginal hormones don’t raise clotting risks or estrone levels, and they protect the uterine lining. Multiple clinical trials show
controlled absorption and a strong safety profile compared to oral forms.Endometrial protection • Vaginal progesterone uses the “first uterine pass effect” to deliver high local levels directly to the uterus, maximizing protection and turn over of the lining, while reducing risks tied to oral forms.
Clinically validated • Multiple randomized trials confirm that vaginal estradiol and progesterone are safe, effective, and superior for
predictable hormone delivery and endometrial health.
How to use
How to use
How to apply:
Apply vaginally once daily, in AM or PM. One pump is the measured amount. Do not use any other amount.
Push down once on the top of the bottle until cream dispenses one pearl-sized dose. Shake the bottle if the cream doesn’t dispense after the first few pumps. This is to remove any potential air pockets.
Use your finger to apply to vaginal tissue, in the opening or underside of the labia (the mucosal tissue, not the skin).
Use and store at room temperature. Keep out of reach of children and pets. Dispose of in the trash when empty or expired.
If you miss a dose, resume when you remember. Missed doses can result in a withdrawal bleed.
Stop on day 27 of your 28-day cycle to have a period (if you have a uterus and want to mimic your natural rhythm). Do not use while bleeding. You can resume again once bleeding has stopped, or once 2 days have passed and there is little to no bleeding.
Contact our care team if you don’t want to have a monthly period.One pump lasts ~24 hours.
How Oestra® works
How Oestra® works
Oestra® enriches your existing hormone levels rather than replacing them. This helps regulate menstrual cycles, improve sleep and mood, and support energy levels through a fluctuating hormonal landscape.
It is absorbed through the vaginal lining and goes into your bloodstream systemically.
It bypasses liver metabolism to lower the chance of making unwanted liver byproducts.
It keeps hormone levels steady and reliable.
It works throughout your whole body – not just the vaginal area.How Oestra® works
Storage instructions
Storage instructions
Store Oestra® at room temperature. Avoid heat or direct sunlight. Always secure the cap to maintain product integrity .
Oestra® ingredients
Oestra® ingredients
Third-party tested for potency, purity & quality.
One pump contains:
0.3% Estradiol
10% Progesterone
Cream base*
*MCT oil, hydrogenated vegan fat, polyoxyl stearate, glyceryl monostearate & ricinoleate, poloxamer 407 and polyoxyl 20 cetostearyl ether
Understanding labs
Understanding labs
You don’t need labs to start or monitor Oestra® but some women find them helpful to track progress or fine-tune treatment.
Important: Skip Oestra® for 24-48 hours before testing. This gives you a “steady state” reading instead of a temporary peak right after application. *Wait 2-3 months before getting labs.
Helpful labs:
Progesterone
Testosterone
Estradiol
FSH
Target levels for 1 pump/day:
Estradiol: 100-300 pg/mL
Testosterone: 10-30 ng/dL
Progesterone: 2.0-6.0 ng/mL
FSH: 1.0-8.0
What to mindful of
What to mindful of
Its purpose: To treat over 100 symptoms of low estrogen, progesterone and testosterone, such as:
Heavy and/or painful periods, anxiety, depression, irritability, insomnia, vaginal dryness, low libido, hair loss, dry skin, dry mouth, dry eyes, fatigue, brain fog, joint and muscle pain, and more
Symptoms of endometriosis, postpartum, PCOS, perimenopause and menopause++
Drug interactions:If you take any mental health medications, mood changes may happen at first but tend to level out. You may need extra monitoring or support, contact us if needed.
If you’re on thyroid medicine or have low thyroid (hypothyroidism), you may need extra monitoring or support, contact us if needed.
Stop using hormone herbs or detoxers like black cohosh, chaste berry or DIM.
Rifampin, phenobarbital, carbamazepine, and St. John’s Wort can reduce the hormone’s efficacy.
Keto/itraconazole, clarithromycin, ritonavir, and grapefruit juice can slow how your body processes Oestra®.
If you’re taking warfarin, you may need extra INR blood tests.
When it shouldn't be used
When it shouldn't be used
As a contraceptive or to prevent pregnancy
During known or suspected pregnancy
When undergoing treatment for a blood clot
With severe liver disease
When undergoing dialysis
When undergoing treatment for cancer