Oestra® is a cream applied vaginally, which allows it to be absorbed directly into the bloodstream. This method bypasses the gut and liver, helping your hormones get where they’re needed faster and more effectively.
Systemic and highly bioavailable • Vaginal delivery bypasses liver metabolism, allowing nearly full absorption of estradiol and progesterone—far better than oral (10-20%) or topical (3-20%). This leads to more stable hormone levels and better symptom control.
More effective, fewer side effects • It delivers consistent results with fewer fluctuations and side effects. Hormone levels remain steady, improving your comfort and results. Clinical evidence—including 100+ studies—supports its effectiveness.
Proven safety • Vaginal hormones don’t raise clotting risks or estrone levels, and they protect the uterine lining. Multiple clinical trials show
controlled absorption and a strong safety profile compared to oral forms.
Endometrial protection • Vaginal progesterone uses the “first uterine pass effect” to deliver high local levels directly to the uterus, maximizing protection and turn over of the lining, while reducing risks tied to oral forms.
Clinically validated • Multiple randomized trials confirm that vaginal estradiol and progesterone are safe, effective, and superior for
predictable hormone delivery and endometrial health.