Why does Oestra® contain all three hormones?
Why does Oestra® contain all three hormones?
Oestra® is designed to prevent dominance of testosterone or estradiol, which is a common problem when hormones are given one at a time. Raising all three hormones together in the correct ratio is crucial for achieving true balance and symptom relief without creating new side effects.
Will I still have a period? Do I have to stop the cream to have one?
Will I still have a period? Do I have to stop the cream to have one?
Yes, Oestra® does not stop your natural cycle or ovulation. To have a period, you should stop the cream for 2-3 days every 28 days. This mimics the natural drop in hormones that triggers a withdrawal bleed, allowing the uterine lining to shed. It is not recommended to apply the cream while bleeding, as it won't absorb properly.
I have a lot of cramping. Is this normal?
I have a lot of cramping. Is this normal?
Yes, cramping is common when first starting Oestra® and is due to increased blood flow and tone in the uterus. While uncomfortable, it's a normal part of the adjustment process and typically resolves on its own within 14 days. Magnesium, particularly in Epsom salt baths, is very effective at reducing cramps.
Can I get pregnant while taking Oestra®?
Can I get pregnant while taking Oestra®?
Yes. Oestra® is not a form of birth control and does not prevent ovulation. We recommend non-oral forms of birth control (like an IUD) if you are using it alongside Oestra™.
Why don't you require lab tests before starting?
Why don't you require lab tests before starting?
Labs are often unreliable for perimenopause because hormones fluctuate constantly. Many women have significant symptoms even when their labs fall within "normal" ranges. There is also no way to predict an optimal dose from a lab test alone. Our approach is to treat your symptoms, starting you on a carefully selected dose and adjusting based on how you feel and respond.
What if I want to check my lab levels?
What if I want to check my lab levels?
While we don't require it, you can follow your labs. Be sure to SKIP Oestra® for a full 24-48 hours before the test to get a "steady state" reading, not a misleading peak value . Expected steady-state ranges on the starting dose are typically Estradiol: 100-400 pg/mL and Progesterone: 2.0-6.0 ng/mL.
What about the FDA Black Box Warning?
What about the FDA Black Box Warning?
The FDA requires this warning on all estradiol products, based on outdated studies of synthetic hormones (progestins) and oral estrogen taken without progesterone . The FDA's current labeling does not differentiate between those synthetic formulas and modern bioidentical therapies like Oestra®, which uses bioidentical progesterone known to be protective. Subsequent research has shown that when used appropriately with bioidentical progesterone, estrogen does not increase the risk of cardiovascular events or cancer.